Understanding the Structural and Functional Diversity in Gpcrbetaarrestin Interaction and Signalling

G protein-coupled receptors (GPCRs), also known as seven transmembrane receptors (7TMRs), constitute a large family of cell surface proteins in our genome. They are expressed in various cells and tissues of our body, and perceive an incredibly diverse range of signals including hormones, lipids and metabolites. Nearly every aspect of human physiology including memory, cognition, behavior, cardiovascular regulation and immune response is governed by these receptors making them one of the most sought-after targets for modern medicine. Although majority of signaling and regulatory para-digms are conserved across different receptor systems, there is also clear evidence for receptor-specific, tissue-specific and context-specific diversity in their signaling and regulatory paradigms. This project aimed to visualize the intricate details of how these receptors cross-talk with their downstream signal-transducers such as G-proteins and β-arrestins.